| Gene Information | |
|---|---|
| Gene Name | TPBG |
| Organism | Homo sapiens (Human) |
| Gene Length | 420 |
| Protein Names | Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1) |
| Target Name | oncotrophoblast glycoprotein 5t4 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000146242 ) 3 ( ENSG00000283085 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13641 |
| Gene Card | TPBG |
| Uniprot ID | Q13641 |
| Pfam | PF13855; PF01463; PF01462 |
| In ASD | no |
| Allosteric Prediction | no (-1.279901196) |
| Ortholog in Animals | Alpaca_ TPBG ( ortholog_one2one ) Dog_ TPBG ( ortholog_one2one ) GuineaPig_ TPBG ( ortholog_one2one ) Macaque_ TPBG ( ortholog_one2one ) Mouse_ Tpbg ( ortholog_one2one ) Pig_ TPBG ( ortholog_one2one ) Rat_ Tpbg ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4CNC (X-ray 1.77A ) 4CNM (X-ray 1.75A ) 6HBY (X-ray 1.95A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}. |
| Mouse PG classification | NA |
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