| Gene Information | |
|---|---|
| Gene Name | BMX |
| Organism | Homo sapiens (Human) |
| Gene Length | 675 |
| Protein Names | Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) |
| Target Name | cytoplasmic tyrosine-protein kinase bmx |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000102010 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P51813 |
| Gene Card | BMX |
| Uniprot ID | P51813 |
| Pfam | PF00779; PF00169; PF07714; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.474792297) |
| Ortholog in Animals | Alpaca_ BMX ( ortholog_one2one ) Dog_ BMX ( ortholog_one2one ) GuineaPig_ BMX ( ortholog_one2one ) Macaque_ BMX ( ortholog_one2one ) Mouse_ Bmx ( ortholog_one2one ) Pig_ BMX ( ortholog_one2one ) Rat_ Bmx ( ortholog_one2one ) Rabbit_ BMX ( ortholog_one2one ) |
| Ohnologs | BTK, ITK |
| Paralogs | FGR, FRK, JAK3, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EKX (NMR - ) 2YS2 (NMR - ) 3SXR (X-ray 2.40A ) 3SXS (X-ray 1.89A ) 6I99 (X-ray 2.00A ) |
| DBSNP | rs35353387 rs1029888196 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1. |
| Mouse PG classification | NA |
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