Gene Information
Gene NameBMPR2
OrganismHomo sapiens (Human)
Gene Length1038
Protein NamesBone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Target Namebone morphogenetic protein receptor type-2
Target TypeNA
Gene Age987 ( ENSG00000204217 )
Evolutionary StageEumetazoa
AlphaFoldDBQ13873
Gene CardBMPR2
Uniprot IDQ13873
PfamPF01064; PF00069
In ASDno
Allosteric Predictionyes (0.180746142)
Ortholog in AnimalsAlpaca_ BMPR2 ( ortholog_one2one )
Dog_ BMPR2 ( ortholog_one2one )
GuineaPig_ BMPR2 ( ortholog_one2one )
Macaque_ BMPR2 ( ortholog_one2one )
Mouse_ Bmpr2 ( ortholog_one2one )
Pig_ BMPR2 ( ortholog_one2one )
Rat_ Bmpr2 ( ortholog_one2one )
Rabbit_ BMPR2 ( ortholog_one2one )
OhnologsNA
ParalogsACVR1, ACVR2A, TGFBR2, ACVR2B, TGFBR1, BMPR1A, AMHR2, ACVR1B, BMPR1B, ACVRL1, ACVR1C
TissueNA
Tissue SpecificityHighly expressed in heart and liver.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2HLQ  (X-ray  1.45A  )  3G2F  (X-ray  2.35A  )  6UNP  (X-ray  2.30A  )  7PPA  (X-ray  1.48A  )  7PPB  (X-ray  2.40A  )  7PPC  (X-ray  3.60A  )  7U5O  (X-ray  3.45A  ) 
DBSNP rs1085307172  rs1085307177  rs1085307185  rs1085307197  rs1085307215  rs137852743  rs137852750  rs137852750  rs137852754  rs754343081  rs767882551  rs137852744  rs1085307324  rs1085307354  rs137852745  rs137852749  rs137852746  rs1085307364  rs1085307365  rs2228545  rs1006246556  rs137852752 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:25187962};
Single-pass type I membrane protein.
Mouse PG classificationHPG
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