Gene Information
Gene NameBMPR1A
OrganismHomo sapiens (Human)
Gene Length532
Protein NamesBone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
Target Namebone morphogenetic protein receptor type-1a
Target TypeNA
Gene Age987 ( ENSG00000107779 )
Evolutionary StageEumetazoa
AlphaFoldDBP36894
Gene CardBMPR1A
Uniprot IDP36894
PfamPF01064; PF07714; PF08515
In ASDno
Allosteric Predictionyes (0.047464994)
Ortholog in AnimalsAlpaca_ BMPR1A ( ortholog_one2one )
Dog_ BMPR1A ( ortholog_one2one )
GuineaPig_ BMPR1A ( ortholog_one2one )
Macaque_ BMPR1A ( ortholog_one2one )
Mouse_ Bmpr1a ( ortholog_one2one )
Pig_ BMPR1A ( ortholog_one2one )
Rat_ Bmpr1a ( ortholog_one2one )
Rabbit_ BMPR1A ( ortholog_one2one )
OhnologsBMPR1B
ParalogsACVR1, BMPR2, ACVR2A, TGFBR2, ACVR2B, TGFBR1, AMHR2, ACVR1B, BMPR1B, ACVRL1, ACVR1C
TissueNA
Tissue SpecificityHighly expressed in skeletal muscle.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ES7  (X-ray  2.90A  )  1REW  (X-ray  1.86A  )  2GOO  (X-ray  2.20A  )  2H62  (X-ray  1.85A  )  2H64  (X-ray  1.92A  )  2K3G  (NMR  -  )  2QJ9  (X-ray  2.44A  )  2QJA  (X-ray  2.60A  )  2QJB  (X-ray  2.50A  )  3NH7  (X-ray  2.70A  )  3QB4  (X-ray  2.28A  ) 
DBSNP rs11528010  rs199476087  rs1131691168  rs199476086  rs199476088  rs35619497  rs55932635  rs758309022  rs199476089  rs752802257 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:P36898};
Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P36895}.
Mouse PG classificationLPG
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