| Gene Information | |
|---|---|
| Gene Name | BMP7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 431 |
| Protein Names | Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa) |
| Target Name | bone morphogenetic protein 7 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000101144 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P18075 |
| Gene Card | BMP7 |
| Uniprot ID | P18075 |
| Pfam | PF00019; PF00688 |
| In ASD | no |
| Allosteric Prediction | no (-0.288956512) |
| Ortholog in Animals | Alpaca_ BMP7 ( ortholog_one2one ) Dog_ BMP7 ( ortholog_one2one ) GuineaPig_ BMP7 ( ortholog_one2one ) Macaque_ BMP7 ( ortholog_one2one ) Mouse_ Bmp7 ( ortholog_one2one ) Pig_ BMP7 ( ortholog_one2one ) Rat_ Bmp7 ( ortholog_one2one ) |
| Ohnologs | BMP5, BMP8B, BMP6, BMP8A |
| Paralogs | BMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | NA |
| Tissue Specificity | Expressed in the kidney and bladder. Lower levels seen in the brain. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.053774(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BMP (X-ray 2.80A ) 1LX5 (X-ray 3.30A ) 1LXI (X-ray 2.00A ) 1M4U (X-ray 2.42A ) |
| DBSNP | rs376798352 rs61733438 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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