| Gene Information | |
|---|---|
| Gene Name | MTAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 283 |
| Protein Names | S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) |
| Target Name | s-methyl-5'-thioadenosine phosphorylase |
| Target Type | Literature-reported target |
| Gene Age | 1292 ( ENSG00000099810 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q13126 |
| Gene Card | MTAP |
| Uniprot ID | Q13126 |
| Pfam | PF01048 |
| In ASD | no |
| Allosteric Prediction | yes (0.751719541) |
| Ortholog in Animals | Alpaca_ MTAP ( ortholog_one2one ) Dog_ MTAP ( ortholog_one2one ) Macaque_ MTAP ( ortholog_one2one ) Mouse_ Mtap ( ortholog_one2one ) Pig_ MTAP ( ortholog_one2one ) Rat_ Mtap ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PNP |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CB0 (X-ray 1.70A ) 1CG6 (X-ray 1.70A ) 1K27 (X-ray 1.95A ) 1SD1 (X-ray 2.03A ) 1SD2 (X-ray 2.10A ) 3LN5 (X-ray 1.90A ) 3OZC (X-ray 1.93A ) 3OZD (X-ray 2.10A ) 3OZE (X-ray 2.00A ) 5EUB (X-ray 1.81A ) 5TC5 (X-ray 1.96A ) 5TC6 (X-ray 1.48A ) 5TC7 (X-ray 1.75A ) 5TC8 (X-ray 1.80A ) 6DYZ (X-ray 1.62A ) 6DZ0 (X-ray 1.62A ) 6DZ2 (X-ray 1.99A ) 6DZ3 (X-ray 1.91A ) |
| DBSNP | rs7023954 |
| Subcellular location [CC] | Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03155}. |
| Mouse PG classification | NA |
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