Gene Information
Gene NameDLG2
OrganismHomo sapiens (Human)
Gene Length576
Protein NamesMAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000150672 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ14168
Gene CardMPP2
Uniprot IDQ14168
PfamPF00625; PF02828; PF00595; PF07653
In ASDno
Allosteric Predictionyes (1.294347857)
Ortholog in AnimalsAlpaca_ DLG2 ( ortholog_one2one )
Dog_ DLG2 ( ortholog_one2one )
GuineaPig_ DLG2 ( ortholog_one2one )
Macaque_ DLG2 ( ortholog_one2one )
Mouse_ Dlg2 ( ortholog_one2one )
Pig_ DLG2 ( ortholog_one2one )
Rat_ Dlg2 ( ortholog_one2one )
Rabbit_ DLG2 ( ortholog_one2one )
OhnologsDLG3, DLG4, DLG1
ParalogsDLG1, DLG4, DLG3
Tissuecerebral.cortex
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2E7K  (NMR 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19665017}. Membrane {ECO:0000269|PubMed:19665017}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WV34}. Postsynaptic density {ECO:0000250|UniProtKB:Q9WV34}. Note=Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts. {ECO:0000250|UniProtKB:Q9WV34}.
Mouse PG classificationNA
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