| Gene Information | |
|---|---|
| Gene Name | MAP3K15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1313 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) |
| Target Name | mitogen-activated protein kinase kinase kinase 15 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000180815 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6ZN16 |
| Gene Card | MAP3K15 |
| Uniprot ID | Q6ZN16 |
| Pfam | PF19039; PF20309; PF20302; PF13281; PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.09047559) |
| Ortholog in Animals | Alpaca_ MAP3K15 ( ortholog_one2one ) Dog_ MAP3K15 ( ortholog_one2one ) GuineaPig_ MAP3K15 ( ortholog_one2one ) Macaque_ MAP3K15 ( ortholog_one2one ) Mouse_ Map3k15 ( ortholog_one2one ) Pig_ MAP3K15 ( ortholog_one2one ) Rat_ AABR07038029.1 ( ortholog_one2one ) Rabbit_ MAP3K15 ( ortholog_one2one ) |
| Ohnologs | MAP3K6, MAP3K5 |
| Paralogs | MAP3K5, MAP3K6 |
| Tissue | adrenal.gland |
| Tissue Specificity | Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen. {ECO:0000269|PubMed:20362554}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6V0M (X-ray 1.80A ) |
| DBSNP | rs5909299 rs55916006 rs56338727 rs56212339 rs41305349 rs56381411 rs56233219 rs55787622 rs15943 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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