Gene Information | |
---|---|
Gene Name | BLNK |
Organism | Homo sapiens (Human) |
Gene Length | 456 |
Protein Names | B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) |
Target Name | NA |
Target Type | NA |
Gene Age | 645 ( ENSG00000095585 ) |
Evolutionary Stage | Vertebrata |
AlphaFoldDB | Q8WV28 |
Gene Card | BLNK |
Uniprot ID | Q8WV28 |
Pfam | PF00017 |
In ASD | no |
Allosteric Prediction | no (-0.54096985) |
Ortholog in Animals | Alpaca_ BLNK ( ortholog_one2one ) Dog_ BLNK ( ortholog_one2one ) GuineaPig_ BLNK ( ortholog_one2one ) Macaque_ BLNK ( ortholog_one2one ) Mouse_ Blnk ( ortholog_one2one ) Pig_ BLNK ( ortholog_one2one ) Rat_ Blnk ( ortholog_one2one ) Rabbit_ BLNK ( ortholog_one2one ) |
Ohnologs | LCP2, CLNK |
Paralogs | CLNK, SH2D6, LCP2 |
Tissue | esophagus.mucosa, spleen |
Tissue Specificity | Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.04(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 6YLU (X-ray 1.88A ) |
DBSNP | NA |
Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction. |
Mouse PG classification | NA |
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