Gene Information
Gene NameBLNK
OrganismHomo sapiens (Human)
Gene Length456
Protein NamesB-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000095585 )
Evolutionary StageVertebrata
AlphaFoldDBQ8WV28
Gene CardBLNK
Uniprot IDQ8WV28
PfamPF00017
In ASDno
Allosteric Predictionno (-0.54096985)
Ortholog in AnimalsAlpaca_ BLNK ( ortholog_one2one )
Dog_ BLNK ( ortholog_one2one )
GuineaPig_ BLNK ( ortholog_one2one )
Macaque_ BLNK ( ortholog_one2one )
Mouse_ Blnk ( ortholog_one2one )
Pig_ BLNK ( ortholog_one2one )
Rat_ Blnk ( ortholog_one2one )
Rabbit_ BLNK ( ortholog_one2one )
OhnologsLCP2, CLNK
ParalogsCLNK, SH2D6, LCP2
Tissueesophagus.mucosa, spleen
Tissue SpecificityExpressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.04(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6YLU  (X-ray  1.88A 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction.
Mouse PG classificationNA
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