| Gene Information | |
|---|---|
| Gene Name | BLK |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) |
| Target Name | tyrosine-protein kinase blk |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000136573 ) 3 ( ENSG00000285369 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P51451 |
| Gene Card | BLK |
| Uniprot ID | P51451 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.874828653) |
| Ortholog in Animals | Alpaca_ BLK ( ortholog_one2one ) Dog_ BLK ( ortholog_one2one ) GuineaPig_ BLK ( ortholog_one2one ) Macaque_ BLK ( ortholog_one2one ) Mouse_ Blk ( ortholog_one2one ) Pig_ BLK ( ortholog_one2one ) Rat_ Blk ( ortholog_one2one ) Rabbit_ BLK ( ortholog_one2one ) |
| Ohnologs | HCK, YES1, SRC, FGR, LCK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | lymph.node, spleen, appendix, tonsil |
| Tissue Specificity | Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. {ECO:0000269|PubMed:19667185}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35339715 rs55758736 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). {ECO:0000250}. |
| Mouse PG classification | LPG |
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