| Gene Information | |
|---|---|
| Gene Name | BITH |
| Organism | Homo sapiens (Human) |
| Gene Length | 96 |
| Protein Names | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NP97 |
| Gene Card | DYNLRB1 |
| Uniprot ID | Q9NP97 |
| Pfam | PF03259 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients. {ECO:0000269|PubMed:11750132}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.090523(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z09 (NMR - ) 2B95 (NMR - ) 2E8J (NMR - ) 2HZ5 (X-ray 2.10A ) 6F1T (EM 3.50A ) 6F1Z (EM 3.40A ) 6F38 (EM 6.70A ) 6F3A (EM 8.20A ) 6RLB (EM 4.50A ) 6SC2 (EM 3.90A ) 7Z8F (EM 20.00A ) |
| DBSNP | rs1063616 rs10036 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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