| Gene Information | |
|---|---|
| Gene Name | BIT |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P78324 |
| Gene Card | SIRPA |
| Uniprot ID | P78324 |
| Pfam | PF07654; PF07686 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JJS (X-ray 1.85A ) 2JJT (X-ray 2.30A ) 2UV3 (X-ray 1.80A ) 2WNG (X-ray 2.49A ) 4CMM (X-ray 1.92A ) 6BIT (X-ray 2.19A ) 6NMR (X-ray 2.42A ) 6NMS (X-ray 2.11A ) 6NMT (X-ray 1.83A ) 6NMU (X-ray 2.55A ) 6NMV (X-ray 2.61A ) 7KPG (X-ray 2.27A ) |
| DBSNP | rs1349896458 rs143735290 rs17855609 rs17855610 rs17855611 rs17855612 rs1371837011 rs1057114 rs1182420620 rs138283486 rs386811662 rs17855615 rs17855616 rs767136065 rs386811663 rs143385810 rs377448893 rs754806675 rs2422666 rs138876160 rs1200233096 rs778218860 rs1168490568 rs367629199 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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