| Gene Information | |
|---|---|
| Gene Name | BIRC6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4857 |
| Protein Names | Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115760 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | BIRC6 |
| Uniprot ID | Q9NR09 |
| Pfam | PF00653; PF12356; PF00179 |
| In ASD | no |
| Allosteric Prediction | yes (0.137400786) |
| Ortholog in Animals | Alpaca_ BIRC6 ( ortholog_one2one ) GuineaPig_ BIRC6 ( ortholog_one2one ) Macaque_ BIRC6 ( ortholog_one2one ) Mouse_ Birc6 ( ortholog_one2one ) Pig_ BIRC6 ( ortholog_one2one ) Rat_ Birc6 ( ortholog_one2one ) Rabbit_ BIRC6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NAIP, BIRC2, BIRC3, XIAP, BIRC7, NLRC4, BIRC5 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain cancer cells. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02963(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3CEG (X-ray 2.01A ) |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Midbody, Midbody ring {ECO:0000269|PubMed:18329369}. Note=Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369). {ECO:0000269|PubMed:18329369}. |
| Mouse PG classification | NA |
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