Gene Information
Gene NameBIRC5
OrganismHomo sapiens (Human)
Gene Length142
Protein NamesBaculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Target Nameapoptosis inhibitor survivin
Target TypeClinical trial target
Gene Age680 ( ENSG00000089685 )
Evolutionary StageOpisthokonta
AlphaFoldDBO15392
Gene CardBIRC5
Uniprot IDO15392
PfamPF00653
In ASDyes
Allosteric Predictionyes (0.501307685)
Ortholog in AnimalsAlpaca_ BIRC5 ( ortholog_one2one )
GuineaPig_ BIRC5 ( ortholog_one2one )
Mouse_ Birc5 ( ortholog_one2one )
Pig_ BIRC5 ( ortholog_one2one )
Rat_ Birc5 ( ortholog_one2one )
OhnologsNA
ParalogsNAIP, BIRC2, BIRC3, XIAP, BIRC7, NLRC4, BIRC6
Tissuebrain, testis
Tissue SpecificityExpressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:14741722, ECO:0000269|PubMed:16329164, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:21364656}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1E31  (X-ray  2.71A  )  1F3H  (X-ray  2.58A  )  1XOX  (NMR  -  )  2QFA  (X-ray  1.40A  )  2RAW  (X-ray  2.40A  )  2RAX  (X-ray  3.30A  )  3UEC  (X-ray  2.18A  )  3UED  (X-ray  2.70A  )  3UEE  (X-ray  2.61A  )  3UEF  (X-ray  2.45A  )  3UEG  (X-ray  2.80A  )  3UEH  (X-ray  2.60A  )  3UEI  (X-ray  2.70A  )  3UIG  (X-ray  2.40A  )  3UIH  (X-ray  2.40A  )  3UII  (X-ray  2.60A  )  3UIJ  (X-ray  2.70A  )  3UIK  (X-ray  2.70A  )  4A0I  (X-ray  2.60A  )  4A0J  (X-ray  2.80A  )  4A0N  (X-ray  2.74A  )  6SHO  (X-ray  3.20A  )  6YIE  (X-ray  3.49A  )  6YIF  (X-ray  1.81A  )  6YIH  (X-ray  2.55A  )  7LBK  (X-ray  2.70A  )  7LBO  (X-ray  2.50A  )  7LBP  (X-ray  2.60A  )  7LBQ  (X-ray  2.69A  ) 
DBSNP rs2071214 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Nucleus {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Chromosome {ECO:0000269|PubMed:14610074}. Chromosome, centromere {ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:16322459}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11084331}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11084331}. Midbody {ECO:0000269|PubMed:15665297}. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody (PubMed:11084331). Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074). Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784). {ECO:0000250|UniProtKB:E3SCZ8, ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:20826784}.
Mouse PG classificationNA
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