| Gene Information | |
|---|---|
| Gene Name | BIRC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 142 |
| Protein Names | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) |
| Target Name | baculoviral iap repeat-containing protein 5 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000089685 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O15392 |
| Gene Card | BIRC5 |
| Uniprot ID | O15392 |
| Pfam | PF00653 |
| In ASD | yes |
| Allosteric Prediction | yes (0.501307685) |
| Ortholog in Animals | Alpaca_ BIRC5 ( ortholog_one2one ) GuineaPig_ BIRC5 ( ortholog_one2one ) Mouse_ Birc5 ( ortholog_one2one ) Pig_ BIRC5 ( ortholog_one2one ) Rat_ Birc5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NAIP, BIRC2, BIRC3, XIAP, BIRC7, NLRC4, BIRC6 |
| Tissue | brain, testis |
| Tissue Specificity | Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:14741722, ECO:0000269|PubMed:16329164, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:21364656}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E31 (X-ray 2.71A ) 1F3H (X-ray 2.58A ) 1XOX (NMR - ) 2QFA (X-ray 1.40A ) 2RAW (X-ray 2.40A ) 2RAX (X-ray 3.30A ) 3UEC (X-ray 2.18A ) 3UED (X-ray 2.70A ) 3UEE (X-ray 2.61A ) 3UEF (X-ray 2.45A ) 3UEG (X-ray 2.80A ) 3UEH (X-ray 2.60A ) 3UEI (X-ray 2.70A ) 3UIG (X-ray 2.40A ) 3UIH (X-ray 2.40A ) 3UII (X-ray 2.60A ) 3UIJ (X-ray 2.70A ) 3UIK (X-ray 2.70A ) 4A0I (X-ray 2.60A ) 4A0J (X-ray 2.80A ) 4A0N (X-ray 2.74A ) 6SHO (X-ray 3.20A ) 6YIE (X-ray 3.49A ) 6YIF (X-ray 1.81A ) 6YIH (X-ray 2.55A ) 7LBK (X-ray 2.70A ) 7LBO (X-ray 2.50A ) 7LBP (X-ray 2.60A ) 7LBQ (X-ray 2.69A ) |
| DBSNP | rs2071214 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Nucleus {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Chromosome {ECO:0000269|PubMed:14610074}. Chromosome, centromere {ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:16322459}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11084331}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11084331}. Midbody {ECO:0000269|PubMed:15665297}. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody (PubMed:11084331). Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074). Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784). {ECO:0000250|UniProtKB:E3SCZ8, ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:20826784}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |