| Gene Information | |
|---|---|
| Gene Name | PIN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 131 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000102309 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y237 |
| Gene Card | PIN4 |
| Uniprot ID | Q9Y237 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.036489715) |
| Ortholog in Animals | Alpaca_ PIN4 ( ortholog_one2one ) Dog_ PIN4 ( ortholog_one2one ) GuineaPig_ PIN4 ( ortholog_one2one ) Macaque_ PIN4 ( ortholog_one2one ) Mouse_ Pin4 ( ortholog_one2one ) Pig_ PIN4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PIN1 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed. {ECO:0000269|PubMed:10100858, ECO:0000269|PubMed:10364457, ECO:0000269|PubMed:16522211}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EQ3 (NMR - ) 1FJD (NMR - ) 3UI4 (X-ray 0.80A ) 3UI5 (X-ray 1.40A ) 3UI6 (X-ray 0.89A ) |
| DBSNP | rs6525589 rs7058353 |
| Subcellular location [CC] | [Isoform 1]: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.; [Isoform 2]: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide. |
| Mouse PG classification | NA |
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