Gene Information
Gene NameLCAT
OrganismHomo sapiens (Human)
Gene Length440
Protein NamesPhosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)
Target Namelecithin-cholesterol acyltransferase
Target TypeClinical trial target
Gene Age544 ( ENSG00000213398 )
Evolutionary StageEukaryota
AlphaFoldDBP04180
Gene CardLCAT
Uniprot IDP04180
PfamPF02450
In ASDno
Allosteric Predictionyes (0.626195714)
Ortholog in AnimalsAlpaca_ LCAT ( ortholog_one2one )
GuineaPig_ LCAT ( ortholog_one2one )
Macaque_ LCAT ( ortholog_one2one )
Mouse_ Lcat ( ortholog_one2one )
Pig_ LCAT ( ortholog_one2one )
Rat_ Lcat ( ortholog_one2one )
Rabbit_ LCAT ( ortholog_one2one )
OhnologsNA
ParalogsPLA2G15
TissueNA
Tissue SpecificityDetected in blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Detected in cerebral spinal fluid (at protein level) (PubMed:10222237). Detected in liver (PubMed:3797244, PubMed:3458198). Expressed mainly in brain, liver and testes. {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3458198, ECO:0000269|PubMed:3797244, ECO:0000269|PubMed:8820107}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.1(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4X96  (X-ray  8.69A  )  4XWG  (X-ray  2.65A  )  4XX1  (X-ray  3.60A  )  5BV7  (X-ray  2.45A  )  5TXF  (X-ray  3.10A  )  6MVD  (X-ray  3.10A  ) 
DBSNP rs121908051  rs971887742  rs1461145750  rs748427834  rs1412883954  rs28940886  rs140068549  rs121908050  rs768017317  rs28940887  rs1380009545  rs769485083  rs1369994093  rs749740660  rs387906300  rs4986970  rs28942087  rs121908049  rs745320775  rs780824776  rs121908054  rs121908048  rs1407191796  rs776035233  rs1330635214  rs28940888  rs202017590  rs121908053 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:19065001, ECO:0000269|PubMed:3458198, ECO:0000269|PubMed:8016111, ECO:0000269|PubMed:8820107}. Note=Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (PubMed:10222237). {ECO:0000269|PubMed:10222237, ECO:0000269|PubMed:3458198, ECO:0000269|PubMed:8820107}.
Mouse PG classificationHPG
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