| Gene Information | |
|---|---|
| Gene Name | BCL2L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 193 |
| Protein Names | Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) |
| Target Name | apoptosis regulator bcl-w |
| Target Type | Clinical trial target |
| Gene Age | 3 ( ENSG00000129473 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q92843 |
| Gene Card | BCL2L2;BCL2L2-PABPN1 |
| Uniprot ID | Q92843 |
| Pfam | PF00452; PF02180 |
| In ASD | no |
| Allosteric Prediction | no (-0.59738802) |
| Ortholog in Animals | GuineaPig_ BCL2L2 ( ortholog_one2one ) Mouse_ Bcl2l2 ( ortholog_one2one ) Pig_ BCL2L2 ( ortholog_one2one ) Rat_ Bcl2l2 ( ortholog_one2one ) Rabbit_ BCL2L2 ( ortholog_one2one ) |
| Ohnologs | BCL2L1, BCL2 |
| Paralogs | BAX, BCL2L10, BOK, MCL1, BCL2A1, BAK1, BCL2L1, BCL2 |
| Tissue | NA |
| Tissue Specificity | Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. {ECO:0000269|PubMed:11423909}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.0375(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MK3 (NMR - ) 1O0L (NMR - ) 1ZY3 (NMR - ) 2Y6W (X-ray 2.00A ) 4CIM (X-ray 1.50A ) |
| DBSNP | rs910332 |
| Subcellular location [CC] | Mitochondrion membrane {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}; Peripheral membrane protein {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane. |
| Mouse PG classification | NA |
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