Gene Information
Gene NameBIN1
OrganismHomo sapiens (Human)
Gene Length593
Protein NamesMyc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000136717 )
Evolutionary StageEumetazoa
AlphaFoldDBO00499
Gene CardBIN1
Uniprot IDO00499
PfamPF03114; PF14604
In ASDno
Allosteric Predictionyes (0.405551102)
Ortholog in AnimalsAlpaca_ BIN1 ( ortholog_one2one )
Dog_ BIN1 ( ortholog_one2one )
GuineaPig_ BIN1 ( ortholog_one2one )
Macaque_ BIN1 ( ortholog_one2one )
Mouse_ Bin1 ( ortholog_one2one )
Pig_ BIN1 ( ortholog_one2one )
Rat_ Bin1 ( ortholog_one2one )
Rabbit_ BIN1 ( ortholog_one2one )
OhnologsAMPH, BIN2
ParalogsBIN3, BIN2, AMPH
TissueNA
Tissue SpecificityUbiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle. {ECO:0000269|PubMed:10903846, ECO:0000269|PubMed:27488240, ECO:0000269|PubMed:9182667}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.008(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1MUZ  (NMR  -  )  1MV0  (NMR  -  )  1MV3  (NMR  -  )  2FIC  (X-ray  1.99A  )  2RMY  (NMR  -  )  2RND  (NMR  -  )  5I22  (NMR  -  ) 
DBSNP rs121909273  rs1249621033  rs121909274  rs267606681  rs777176261 
Subcellular location [CC][Isoform BIN1]: Nucleus {ECO:0000269|PubMed:8782822}. Cytoplasm {ECO:0000269|PubMed:9182667}. Endosome {ECO:0000250|UniProtKB:O08539}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08839}.;
[Isoform IIA]: Cytoplasm {ECO:0000269|PubMed:9182667}.
Mouse PG classificationNA
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