| Gene Information | |
|---|---|
| Gene Name | BIGM103 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9C0K1 |
| Gene Card | SLC39A8 |
| Uniprot ID | Q9C0K1 |
| Pfam | PF02535 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:12504855, PubMed:22898811, PubMed:28056086, PubMed:31699897). Expressed in thymus, placenta, lung, liver, pancreas, salivary gland and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas (PubMed:12504855). Expressed by macrophages (at protein level) (PubMed:28056086). Expressed by microvascular capillary endothelial cells that constitute the blood-brain barrier (at protein level) (PubMed:31699897). {ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:22898811, ECO:0000269|PubMed:28056086, ECO:0000269|PubMed:31699897}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs373562040 rs778210210 rs1444255127 rs779241085 rs864309660 rs864309659 rs13107325 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:29337306, ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:12504855, ECO:0000269|PubMed:18390834, ECO:0000269|PubMed:19401385}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:31699897}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the lysosome of activated T-cells (PubMed:19401385). A large fraction of the protein is found intracellularly in microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). Localized and functional at both apical and basolateral membranes of microvascular capillary endothelial cells that constitute the blood-brain barrier (PubMed:31699897). {ECO:0000269|PubMed:19401385, ECO:0000269|PubMed:31699897}. |
| Mouse PG classification | NA |
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