| Gene Information | |
|---|---|
| Gene Name | BIGH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 683 |
| Protein Names | Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q15582 |
| Gene Card | TGFBI |
| Uniprot ID | Q15582 |
| Pfam | PF02469 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the corneal epithelium (PubMed:27609313, PubMed:8077289). Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:8077289). {ECO:0000269|PubMed:27609313, ECO:0000269|PubMed:8077289}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X3B (NMR - ) 2LTB (NMR - ) 2LTC (NMR - ) 2VXP (X-ray 2.50A ) 5NV6 (X-ray 2.93A ) 7AS7 (X-ray 2.65A ) 7ASC (X-ray 4.80A ) 7ASG (X-ray 2.00A ) |
| DBSNP | rs757933370 rs541270955 rs121909210 rs121909211 rs121909211 rs121909210 rs45455404 rs199852470 rs10057190 rs121909212 rs121909216 rs1050842080 rs1382893670 rs121909214 rs777288957 rs267607109 rs267607110 rs121909209 rs121909208 rs121909215 rs1052006472 rs121909217 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:18450759, ECO:0000269|PubMed:26273833, ECO:0000269|PubMed:8024701}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8077289}. Note=May be associated both with microfibrils and with the cell surface (PubMed:8077289). {ECO:0000269|PubMed:8077289}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |