| Gene Information | |
|---|---|
| Gene Name | BICD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 824 |
| Protein Names | Protein bicaudal D homolog 2 (Bic-D 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000185963 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TD16 |
| Gene Card | BICD2 |
| Uniprot ID | Q8TD16 |
| Pfam | PF09730 |
| In ASD | no |
| Allosteric Prediction | no (-0.966595446) |
| Ortholog in Animals | Alpaca_ BICD2 ( ortholog_one2one ) Dog_ BICD2 ( ortholog_one2one ) GuineaPig_ BICD2 ( ortholog_one2one ) Macaque_ BICD2 ( ortholog_one2one ) Mouse_ Bicd2 ( ortholog_one2one ) Pig_ BICD2 ( ortholog_one2one ) Rat_ Bicd2 ( ortholog_one2one ) Rabbit_ BICD2 ( ortholog_one2one ) |
| Ohnologs | BICD1 |
| Paralogs | BICD1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6OFP (X-ray 2.01A ) 6PSE (X-ray 2.40A ) |
| DBSNP | rs61754130 rs398123028 rs398123029 rs1587671674 rs1564061982 rs398123032 rs398123031 rs1064795760 rs797045412 rs371707778 rs398123030 |
| Subcellular location [CC] | Golgi apparatus {ECO:0000269|PubMed:23664116, ECO:0000269|PubMed:23664119}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11864968}. Cytoplasm {ECO:0000269|PubMed:23664116, ECO:0000269|PubMed:23664120}. Nucleus envelope {ECO:0000269|PubMed:20386726}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:20386726}. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (PubMed:20386726). {ECO:0000250|UniProtKB:Q921C5, ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:20386726}. |
| Mouse PG classification | LPG |
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