Gene Information
Gene NamePQBP1
OrganismHomo sapiens (Human)
Gene Length265
Protein NamesPolyglutamine-binding protein 1 (PQBP-1) (38 kDa nuclear protein containing a WW domain) (Npw38) (Polyglutamine tract-binding protein 1)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000102103 )
Evolutionary StageEukaryota
AlphaFoldDBO60828
Gene CardPQBP1
Uniprot IDO60828
PfamNA
In ASDno
Allosteric Predictionno (-0.982451643)
Ortholog in AnimalsAlpaca_ PQBP1 ( ortholog_one2one )
Dog_ PQBP1 ( ortholog_one2one )
GuineaPig_ PQBP1 ( ortholog_one2one )
Macaque_ PQBP1 ( ortholog_one2one )
Mouse_ Pqbp1 ( ortholog_one2one )
Pig_ PQBP1 ( ortholog_one2one )
Rat_ Pqbp1 ( ortholog_one2many )
Rabbit_ PQBP1 ( ortholog_one2one )
OhnologsNA
ParalogsCACTIN, MARVELD3
TissueNA
Tissue SpecificityWidely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4BWQ  (X-ray  2.10A  4BWS  (X-ray  2.50A  4CDO  (X-ray  2.50A 
DBSNP rs121917899  rs878853145 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:23512658}. Nucleus speckle {ECO:0000250|UniProtKB:Q91VJ5}. Cytoplasmic granule {ECO:0000269|PubMed:21933836}. Note=Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2 (PubMed:10332029). Colocalized with ATXN1 in nuclear inclusion bodies (PubMed:12062018). Localizes to cytoplasmic stress granules (PubMed:21933836). {ECO:0000250|UniProtKB:Q91VJ5, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:21933836}.
Mouse PG classificationNA
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