| Gene Information | |
|---|---|
| Gene Name | NR4A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 598 |
| Protein Names | Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000123358 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P22736 |
| Gene Card | NR4A1 |
| Uniprot ID | P22736 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (0.542041906) |
| Ortholog in Animals | Alpaca_ NR4A1 ( ortholog_one2one ) Dog_ NR4A1 ( ortholog_one2one ) GuineaPig_ NR4A1 ( ortholog_one2one ) Macaque_ NR4A1 ( ortholog_one2one ) Mouse_ Nr4a1 ( ortholog_one2one ) Pig_ NR4A1 ( ortholog_one2one ) Rat_ Nr4a1 ( ortholog_one2one ) Rabbit_ NR4A1 ( ortholog_one2one ) |
| Ohnologs | NR4A3, NR4A2 |
| Paralogs | NR4A2, NR4A3 |
| Tissue | NA |
| Tissue Specificity | Fetal muscle and adult liver, brain and thyroid. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2QW4 (X-ray 2.80A ) 3V3E (X-ray 2.06A ) 3V3Q (X-ray 2.22A ) 4JGV (X-ray 3.01A ) 4KZI (X-ray 2.41A ) 4KZJ (X-ray 2.12A ) 4KZM (X-ray 2.30A ) 4RE8 (X-ray 2.16A ) 4REE (X-ray 2.37A ) 4REF (X-ray 2.10A ) 4RZE (X-ray 2.49A ) 4RZF (X-ray 1.99A ) 4RZG (X-ray 2.70A ) 4WHF (X-ray 2.27A ) 4WHG (X-ray 2.18A ) 6KZ5 (X-ray 4.45A ) 6LC1 (X-ray 3.12A ) |
| DBSNP | rs1882118 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:22983157}. Cytoplasm {ECO:0000269|PubMed:15509776, ECO:0000269|PubMed:20438716, ECO:0000269|PubMed:22427340}. Mitochondrion {ECO:0000269|PubMed:17761950}. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). {ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:22427340}. |
| Mouse PG classification | NA |
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