| Gene Information | |
|---|---|
| Gene Name | BHLHA39 |
| Organism | Homo sapiens (Human) |
| Gene Length | 160 |
| Protein Names | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8WVJ9 |
| Gene Card | TWIST2 |
| Uniprot ID | Q8WVJ9 |
| Pfam | PF00010 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. {ECO:0000269|PubMed:11062344}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs796065048 rs796065049 rs796065049 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues. |
| Mouse PG classification | NA |
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