| Gene Information | |
|---|---|
| Gene Name | ASH2L |
| Organism | Homo sapiens (Human) |
| Gene Length | 628 |
| Protein Names | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000129691 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBL3 |
| Gene Card | ASH2L |
| Uniprot ID | Q9UBL3 |
| Pfam | PF00622 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999864236) |
| Ortholog in Animals | Alpaca_ ASH2L ( ortholog_one2one ) Dog_ ASH2L ( ortholog_one2one ) GuineaPig_ ASH2L ( ortholog_one2one ) Macaque_ ASH2L ( ortholog_one2one ) Mouse_ Ash2l ( ortholog_one2one ) Pig_ ASH2L ( ortholog_one2one ) Rat_ Ash2l ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. {ECO:0000269|PubMed:10393421}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.022858(Rat);0.047898(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3RSN (X-ray 2.10A ) 3S32 (X-ray 2.45A ) 3TOJ (X-ray 2.07A ) 4RIQ (X-ray 2.23A ) 4X8N (X-ray 2.10A ) 4X8P (X-ray 2.20A ) 5F6K (X-ray 2.41A ) 5F6L (X-ray 1.90A ) 6E2H (X-ray 2.24A ) 6KIU (EM 3.20A ) 6KIV (EM 4.00A ) 6KIW (EM 4.00A ) 6KIX (EM 4.10A ) 6KIZ (EM 4.50A ) 6PWV (EM 6.20A ) 6W5I (EM 6.90A ) 6W5M (EM 4.60A ) 6W5N (EM 6.00A ) 7BRE (X-ray 2.80A ) 7MBM (EM - ) 7MBN (EM - ) 7W67 (X-ray 2.19A ) 7W6A (X-ray 2.21A ) 7W6I (X-ray 2.56A ) 7W6J (X-ray 2.68A ) 7W6L (X-ray 2.26A ) |
| DBSNP | rs34167006 |
| Subcellular location [CC] | Nucleus {ECO:0000305|PubMed:17355966}. |
| Mouse PG classification | NA |
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