Gene Information
Gene NameBGP1
OrganismHomo sapiens (Human)
Gene Length526
Protein NamesCarcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP13688
Gene CardCEACAM1
Uniprot IDP13688
PfamPF00047; PF13895; PF07686
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in columnar epithelial cells of the colon (at protein level) (PubMed:10436421). The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468). {ECO:0000269|PubMed:10436421, ECO:0000269|PubMed:11994468, ECO:0000269|PubMed:18424730}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2GK2  (X-ray  2.20A  )  4QXW  (X-ray  2.04A  )  4WHD  (X-ray  2.50A  )  5DZL  (X-ray  3.40A  )  6AW2  (X-ray  2.68A  )  6GBG  (X-ray  2.80A  )  6GBH  (X-ray  2.59A  )  6V3P  (X-ray  3.25A  )  6XNO  (X-ray  1.90A  )  6XNT  (X-ray  3.10A  )  6XNW  (X-ray  1.90A  )  6XO1  (X-ray  1.76A  )  7MU8  (X-ray  1.70A  )  7RPP  (X-ray  2.20A  ) 
DBSNP rs8111171  rs8110904  rs8111468  rs41355544 
Subcellular location [CC][Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P16573};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:16291724}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. {ECO:0000250|UniProtKB:P16573}.;
[Isoform 2]: Secreted {ECO:0000269|PubMed:2025273}.;
[Isoform 3]: Secreted {ECO:0000269|PubMed:2025273}.;
[Isoform 4]: Secreted {ECO:0000269|PubMed:2025273}.;
[Isoform 5]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 6]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 7]: Cell membrane;
Single-pass type I membrane protein.;
[Isoform 8]: Cell membrane {ECO:0000269|PubMed:14522961};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:14522961}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:8018919}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). {ECO:0000250|UniProtKB:P16573, ECO:0000269|PubMed:14522961}.;
Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P31809};
Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:10436421};
Single-pass type I membrane protein {ECO:0000305}. Note=Localized to the apical glycocalyx surface (PubMed:10436421). Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:P31809, ECO:0000269|PubMed:10436421}.
Mouse PG classificationNA
click here to return to the previous page