| Gene Information | |
|---|---|
| Gene Name | COL21A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 957 |
| Protein Names | Collagen alpha-1(XXI) chain |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000124749 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96P44 |
| Gene Card | COL21A1 |
| Uniprot ID | Q96P44 |
| Pfam | PF01391; PF00092 |
| In ASD | no |
| Allosteric Prediction | no (-0.662945549) |
| Ortholog in Animals | Alpaca_ COL21A1 ( ortholog_one2one ) Dog_ COL21A1 ( ortholog_one2one ) GuineaPig_ COL21A1 ( ortholog_one2one ) Macaque_ COL21A1 ( ortholog_one2one ) Pig_ COL21A1 ( ortholog_one2one ) Rabbit_ COL21A1 ( ortholog_one2one ) |
| Ohnologs | COL9A3, COL22A1, COL8A1, COL8A2 |
| Paralogs | COL9A2, COLQ, COL4A1, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL25A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL18A1, COL9A1, COL23A1, COL2A1, COL4A2, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL6A1, EMID1, COL4A5, COL4A3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus and placenta; moderately expressed in brain, colon, lung, prostate, spinal cord, salivary gland and vascular smooth-muscle cells and very weakly expressed in heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland and peripheral leukocytes. Expression in heart was higher in the right ventricle and atrium than in the left ventricle and atrium. {ECO:0000269|PubMed:11566190, ECO:0000269|PubMed:11863369}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2764043 rs35471617 rs35583895 rs9382581 rs9464337 rs12209452 rs1555131 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11863369}. Cytoplasm {ECO:0000269|PubMed:11863369}. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle. |
| Mouse PG classification | NA |
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