| Gene Information | |
|---|---|
| Gene Name | BEND3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 828 |
| Protein Names | BEN domain-containing protein 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000178409 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5T5X7 |
| Gene Card | BEND3 |
| Uniprot ID | Q5T5X7 |
| Pfam | PF10523 |
| In ASD | no |
| Allosteric Prediction | no (-1.310837363) |
| Ortholog in Animals | Alpaca_ BEND3 ( ortholog_one2one ) Dog_ BEND3 ( ortholog_one2one ) GuineaPig_ BEND3 ( ortholog_one2one ) Macaque_ BEND3 ( ortholog_one2one ) Mouse_ Bend3 ( ortholog_one2one ) Pig_ BEND3 ( ortholog_one2one ) Rat_ Bend3 ( ortholog_one2one ) Rabbit_ BEND3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at least in heart, kidney, liver, ovary and spleen, with highest levels in spleen and lowest in heart. Expressed on the surface of T-cells. {ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:25400923}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5JNO (X-ray 2.20A ) 7W27 (X-ray 1.49A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21914818, ECO:0000269|PubMed:25600804}. Nucleus, nucleolus {ECO:0000269|PubMed:26100909}. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. {ECO:0000269|PubMed:21914818}. |
| Mouse PG classification | NA |
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