| Gene Information | |
|---|---|
| Gene Name | CAPN8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 703 |
| Protein Names | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000203697 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | A6NHC0 |
| Gene Card | CAPN8 |
| Uniprot ID | A6NHC0 |
| Pfam | PF01067; PF00648 |
| In ASD | no |
| Allosteric Prediction | yes (0.145519963) |
| Ortholog in Animals | Alpaca_ CAPN8 ( ortholog_one2one ) Macaque_ CAPN8 ( ortholog_one2one ) Mouse_ Capn8 ( ortholog_one2one ) Pig_ CAPN8 ( ortholog_one2one ) Rat_ Capn8 ( ortholog_one2one ) Rabbit_ CAPN8 ( ortholog_one2one ) |
| Ohnologs | CAPN11 |
| Paralogs | CAPN1, PEF1, GCA, SRI, CAPN9, PDCD6, CAPN2, CAPN5, CAPN14, CAPN15, CAPN7, ADGB, CAPN6, CAPN3, CAPN12, CAPNS2, CAPN11, CAPN13, CAPNS1, CAPN10 |
| Tissue | stomach, colon, gall.bladder, lung |
| Tissue Specificity | Stomach. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2NQA (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. |
| Mouse PG classification | NA |
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