| Gene Information | |
|---|---|
| Gene Name | BEK |
| Organism | Homo sapiens (Human) |
| Gene Length | 821 |
| Protein Names | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P21802 |
| Gene Card | FGFR2 |
| Uniprot ID | P21802 |
| Pfam | PF07679; PF07714 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002590(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DJS (X-ray 2.40A ) 1E0O (X-ray 2.80A ) 1EV2 (X-ray 2.20A ) 1GJO (X-ray 2.40A ) 1II4 (X-ray 2.70A ) 1IIL (X-ray 2.30A ) 1NUN (X-ray 2.90A ) 1OEC (X-ray 2.40A ) 1WVZ (NMR - ) 2FDB (X-ray 2.28A ) 2PSQ (X-ray 2.40A ) 2PVF (X-ray 1.80A ) 2PVY (X-ray 2.20A ) 2PWL (X-ray 2.40A ) 2PY3 (X-ray 2.30A ) 2PZ5 (X-ray 2.40A ) 2PZP (X-ray 2.40A ) 2PZR (X-ray 3.00A ) 2Q0B (X-ray 2.90A ) 3B2T (X-ray 1.80A ) 3CAF (X-ray 1.96A ) 3CLY (X-ray 2.00A ) 3CU1 (X-ray 2.60A ) 3DAR (X-ray 2.20A ) 3EUU (X-ray 2.34A ) 3OJ2 (X-ray 2.20A ) 3OJM (X-ray 2.10A ) 3RI1 (X-ray 2.10A ) 4J23 (X-ray 3.88A ) 4J95 (X-ray 2.38A ) 4J96 (X-ray 2.30A ) 4J97 (X-ray 2.55A ) 4J98 (X-ray 2.31A ) 4J99 (X-ray 1.85A ) 4WV1 (X-ray 2.36A ) 5EG3 (X-ray 2.61A ) 5UGL (X-ray 1.86A ) 5UGX (X-ray 2.35A ) 5UHN (X-ray 2.91A ) 5UI0 (X-ray 2.05A ) 6AGX (X-ray 2.95A ) 6LVK (X-ray 2.29A ) 6LVL (X-ray 2.98A ) 6V6Q (X-ray 2.46A ) 7KIA (X-ray 2.22A ) 7KIE (X-ray 2.47A ) 7OZY (X-ray 2.28A ) |
| DBSNP | rs3750819 rs56226109 rs1434545235 rs755793 rs281865420 rs121918498 rs79184941 rs79184941 rs77543610 rs779326224 rs121918505 rs121918503 rs1057519036 rs776587763 rs776587763 rs1057519038 rs121918497 rs121918499 rs121918501 rs121918501 rs121918500 rs1554930684 rs1358919643 rs121918504 rs121918510 rs121918493 rs387906676 rs1057519044 rs1057519043 rs1554928884 rs121918489 rs121918495 rs121918487 rs121918488 rs121918488 rs121918488 rs121918496 rs121918487 rs121918492 rs121918494 rs121918502 rs121918490 rs121913477 rs121913478 rs387906678 rs1554927408 rs387906677 rs121918507 rs1057519045 rs121918506 rs121918509 rs1057519047 rs121918508 rs1589722765 rs1845559552 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 8]: Secreted.; [Isoform 13]: Secreted. |
| Mouse PG classification | NA |
| click here to return to the previous page | |