| Gene Information | |
|---|---|
| Gene Name | DEFA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 97 |
| Protein Names | Defensin alpha 4 (Corticostatin HP-4) (HNP-4) (HP-4) (Neutrophil defensin 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 93 ( ENSG00000164821 ) 3 ( ENSG00000285318 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P12838 |
| Gene Card | DEFA4 |
| Uniprot ID | P12838 |
| Pfam | PF00323; PF00879 |
| In ASD | no |
| Allosteric Prediction | no (-0.792179287) |
| Ortholog in Animals | Alpaca_ DEFA4 ( ortholog_one2one ) Mouse_ Defa30 ( ortholog_many2many ) Mouse_ Defa25 ( ortholog_many2many ) Mouse_ Defa31 ( ortholog_many2many ) Mouse_ Defa24 ( ortholog_many2many ) Mouse_ Defa38 ( ortholog_many2many ) Mouse_ Defa20 ( ortholog_many2many ) Mouse_ Defa35 ( ortholog_many2many ) Mouse_ Defa32 ( ortholog_many2many ) Mouse_ AY761185 ( ortholog_many2many ) Mouse_ Defa23 ( ortholog_many2many ) Mouse_ Defa36 ( ortholog_many2many ) Mouse_ Defa33 ( ortholog_many2many ) Mouse_ Defa17 ( ortholog_many2many ) Mouse_ Defa29 ( ortholog_many2many ) Mouse_ Defa39 ( ortholog_many2many ) Mouse_ Defa40 ( ortholog_many2many ) Mouse_ Defa2 ( ortholog_many2many ) Mouse_ Defa22 ( ortholog_many2many ) Mouse_ Defa43 ( ortholog_many2many ) Mouse_ Defa27 ( ortholog_many2many ) Mouse_ Defa26 ( ortholog_many2many ) Mouse_ Defa21 ( ortholog_many2many ) Mouse_ Defa34 ( ortholog_many2many ) Mouse_ Defa42 ( ortholog_many2many ) Mouse_ Defa3 ( ortholog_many2many ) Mouse_ Defa28 ( ortholog_many2many ) Mouse_ Defa41 ( ortholog_many2many ) Mouse_ Defa5 ( ortholog_many2many ) Mouse_ Defa37 ( ortholog_many2many ) Rat_ Defa5 ( ortholog_many2many ) Rat_ Defa24 ( ortholog_many2many ) Rat_ RatNP-3b ( ortholog_many2many ) Rat_ Defa9 ( ortholog_many2many ) Rat_ Defa6 ( ortholog_many2many ) Rat_ Defal1 ( ortholog_many2many ) Rat_ Defa7 ( ortholog_many2many ) Rat_ Defa11 ( ortholog_many2many ) Rat_ Np4 ( ortholog_many2many ) Rat_ Defa10 ( ortholog_many2many ) Rat_ Defa8 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | DEFA1, DEFA3, DEFA1B, DEFA6, DEFA5 |
| Tissue | bone.marrow, left.atrium, left.ventricle, lung, spleen, whole.blood |
| Tissue Specificity | Expressed in neutrophils (at protein level) (PubMed:2843187, PubMed:2500436, PubMed:2501794). Expressed in bone marrow (PubMed:8469233). {ECO:0000269|PubMed:2500436, ECO:0000269|PubMed:2501794, ECO:0000269|PubMed:2843187, ECO:0000269|PubMed:8469233}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZMM (X-ray 1.60A ) 6DMM (X-ray 1.67A ) 6DMQ (X-ray 1.70A ) |
| DBSNP | rs28661751 rs28488529 rs762433303 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:Q01523}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:2500436, ECO:0000269|PubMed:2501794}. Note=Stored as mature peptide in neutrophil granules. {ECO:0000269|PubMed:2500436}. |
| Mouse PG classification | NA |
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