Gene Information
Gene NameBDNF
OrganismHomo sapiens (Human)
Gene Length247
Protein NamesBrain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)]
Target Namebrain-derived neurotrophic factor
Target TypeClinical trial target
Gene Age645 ( ENSG00000176697 )
Evolutionary StageVertebrata
AlphaFoldDBP23560
Gene CardBDNF
Uniprot IDP23560
PfamPF00243
In ASDno
Allosteric Predictionyes (1.494731748)
Ortholog in AnimalsAlpaca_ BDNF ( ortholog_one2one )
Dog_ BDNF ( ortholog_one2one )
GuineaPig_ BDNF ( ortholog_one2one )
Macaque_ BDNF ( ortholog_one2one )
Mouse_ Bdnf ( ortholog_one2one )
Pig_ BDNF ( ortholog_one2one )
Rat_ Bdnf ( ortholog_one2one )
Rabbit_ BDNF ( ortholog_one2one )
OhnologsNTF3, NGF
ParalogsNTF4, NGF, NTF3
TissueNA
Tissue SpecificityDetected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:17629449, ECO:0000269|PubMed:19467646, ECO:0000269|PubMed:2236018}.
Pharmacological Animal Models0.000730(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1B8M  (X-ray  2.75A  )  1BND  (X-ray  2.30A  ) 
DBSNP rs8192466  rs6265  rs1048218  rs765594245  rs1048220  rs1048221 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646, ECO:0000269|PubMed:8527932}.;
[BDNF precursor form]: Secreted {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}. Note=A proportion of BDNF is secreted as immature precursor (proBDNF). {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}.
Mouse PG classificationNA
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