| Gene Information | |
|---|---|
| Gene Name | BCRP |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UNQ0 |
| Gene Card | ABCG2 |
| Uniprot ID | Q9UNQ0 |
| Pfam | PF01061; PF19055; PF00005 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta (PubMed:9850061). Low expression in small intestine, liver and colon (PubMed:9861027). Expressed in brain (at protein level) (PubMed:12958161). {ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:9850061, ECO:0000269|PubMed:9861027}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5NJ3 (EM 3.78A ) 5NJG (EM 3.78A ) 6ETI (EM 3.10A ) 6FEQ (EM 3.60A ) 6FFC (EM 3.56A ) 6HBU (EM 3.09A ) 6HCO (EM 3.58A ) 6HIJ (EM 3.56A ) 6HZM (EM 3.09A ) 6VXF (EM 3.50A ) 6VXH (EM 4.00A ) 6VXI (EM 3.70A ) 6VXJ (EM 4.10A ) 7NEQ (EM 3.12A ) 7NEZ (EM 3.39A ) 7NFD (EM 3.51A ) 7OJ8 (EM 3.40A ) 7OJH (EM 3.10A ) 7OJI (EM 3.40A ) |
| DBSNP | rs2231137 rs1319203095 rs2231142 rs372192400 rs753759474 rs528655917 rs1061017 rs12721643 rs1061018 rs3116448 rs41282401 rs138606116 rs752626614 rs199854112 rs769734146 rs1354553769 rs1274428653 rs192169063 rs45605536 rs9282571 rs200894058 rs34264773 rs34783571 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15001581, ECO:0000269|PubMed:15769853, ECO:0000269|PubMed:15807535, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}. |
| Mouse PG classification | NA |
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