| Gene Information | |
|---|---|
| Gene Name | BCO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 547 |
| Protein Names | Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000135697 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9HAY6 |
| Gene Card | BCO1 |
| Uniprot ID | Q9HAY6 |
| Pfam | PF03055 |
| In ASD | no |
| Allosteric Prediction | no (-0.691527473) |
| Ortholog in Animals | Alpaca_ BCO1 ( ortholog_one2one ) Dog_ BCO1 ( ortholog_one2one ) GuineaPig_ BCO1 ( ortholog_one2one ) Macaque_ BCO1 ( ortholog_one2one ) Mouse_ Bco1 ( ortholog_one2one ) Pig_ BCO1 ( ortholog_one2one ) Rat_ Bco1 ( ortholog_one2one ) Rabbit_ BCO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BCO2, RPE65 |
| Tissue | duodenum, small.intestine |
| Tissue Specificity | Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. {ECO:0000269|PubMed:11401432}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs119478057 rs12934922 rs7501331 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9I993}. |
| Mouse PG classification | NA |
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