| Gene Information | |
|---|---|
| Gene Name | BCLW |
| Organism | Homo sapiens (Human) |
| Gene Length | 193 |
| Protein Names | Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92843 |
| Gene Card | BCL2L2;BCL2L2-PABPN1 |
| Uniprot ID | Q92843 |
| Pfam | PF00452; PF02180 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. {ECO:0000269|PubMed:11423909}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.0375(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MK3 (NMR - ) 1O0L (NMR - ) 1ZY3 (NMR - ) 2Y6W (X-ray 2.00A ) 4CIM (X-ray 1.50A ) |
| DBSNP | rs910332 |
| Subcellular location [CC] | Mitochondrion membrane {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}; Peripheral membrane protein {ECO:0000269|PubMed:11423909, ECO:0000269|PubMed:12952938}. Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane. |
| Mouse PG classification | NA |
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