| Gene Information | |
|---|---|
| Gene Name | BCL6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | B-cell lymphoma 6 protein (BCL-6) (B-cell lymphoma 5 protein) (BCL-5) (Protein LAZ-3) (Zinc finger and BTB domain-containing protein 27) (Zinc finger protein 51) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000113916 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P41182 |
| Gene Card | BCL6 |
| Uniprot ID | P41182 |
| Pfam | PF00651; PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.022494107) |
| Ortholog in Animals | Alpaca_ BCL6 ( ortholog_one2one ) Dog_ BCL6 ( ortholog_one2one ) GuineaPig_ BCL6 ( ortholog_one2one ) Macaque_ BCL6 ( ortholog_one2one ) Mouse_ Bcl6 ( ortholog_one2one ) Pig_ BCL6 ( ortholog_one2one ) Rat_ Bcl6 ( ortholog_one2one ) Rabbit_ BCL6 ( ortholog_one2one ) |
| Ohnologs | BCL6B |
| Paralogs | FEZF1, PRDM12, ZNF280A, ZBTB33, ZBTB21, ZNF280C, NACC2, ZNF580, ZBTB26, NACC1, ZNF683, ZBTB7B, GFI1, PRDM13, ZNF280B, ZBTB6, ZBTB14, GFI1B, ZBTB49, BCL6B, ZBTB3, ZNF581, FEZF2, ZNF280D, ZBTB46, ZNF524, ZBTB12, ZBTB25 |
| Tissue | NA |
| Tissue Specificity | Expressed in germinal center T- and B-cells and in primary immature dendritic cells. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:16455075, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:9649500}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001425(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1R28 (X-ray 2.20A ) 1R29 (X-ray 1.30A ) 1R2B (X-ray 2.20A ) 2EN2 (NMR - ) 2EOS (NMR - ) 2LCE (NMR - ) 2YRM (NMR - ) 3BIM (X-ray 2.60A ) 3E4U (X-ray 2.10A ) 3LBZ (X-ray 2.30A ) 4CP3 (X-ray 2.30A ) 4U2M (X-ray 2.23A ) 5H7G (X-ray 1.85A ) 5H7H (X-ray 1.95A ) 5MW2 (X-ray 2.35A ) 5MW6 (X-ray 1.65A ) 5MWD (X-ray 1.85A ) 5N1X (X-ray 1.72A ) 5N1Z (X-ray 1.81A ) 5N20 (X-ray 1.38A ) 5N21 (X-ray 1.58A ) 5X4M (X-ray 1.65A ) 5X4N (X-ray 1.94A ) 5X4O (X-ray 2.05A ) 5X4P (X-ray 2.06A ) 5X4Q (X-ray 2.00A ) 5X9O (X-ray 1.58A ) 5X9P (X-ray 1.86A ) 6C3L (X-ray 1.46A ) 6C3N (X-ray 2.53A ) 6CQ1 (X-ray 1.70A ) 6EW6 (X-ray 1.39A ) 6EW7 (X-ray 1.60A ) 6EW8 (X-ray 1.84A ) 6TBT (X-ray 1.63A ) 6TCJ (X-ray 2.13A ) 6TOF (X-ray 1.67A ) 6TOG (X-ray 1.69A ) 6TOH (X-ray 1.58A ) 6TOI (X-ray 1.58A ) 6TOJ (X-ray 1.85A ) 6TOK (X-ray 1.43A ) 6TOL (X-ray 1.64A ) 6TOM (X-ray 1.90A ) 6TON (X-ray 2.36A ) 6TOO (X-ray 1.53A ) 6XMX (EM 3.70A ) 6XWF (X-ray 1.60A ) 6XXS (X-ray 3.25A ) 6XYX (X-ray 1.44A ) 6XZZ (X-ray 1.39A ) 6Y17 (X-ray 1.56A ) 6ZBU (X-ray 2.46A ) 7BDE (X-ray 2.04A ) 7LWE (X-ray 1.17A ) 7LWF (X-ray 1.22A ) 7LWG (X-ray 1.30A ) 7LZQ (X-ray 1.71A ) 7LZR (X-ray 1.34A ) 7LZS (X-ray 1.49A ) 7OKD (X-ray 1.94A ) 7OKE (X-ray 1.48A ) 7OKF (X-ray 1.60A ) 7OKG (X-ray 1.32A ) 7OKH (X-ray 1.52A ) 7OKI (X-ray 1.61A ) 7OKJ (X-ray 1.43A ) 7OKK (X-ray 2.05A ) 7OKL (X-ray 1.20A ) 7OKM (X-ray 1.48A ) 7Q7R (X-ray 1.70A ) 7Q7S (X-ray 1.44A ) 7Q7T (X-ray 1.46A ) 7Q7U (X-ray 1.78A ) 7Q7V (X-ray 1.81A ) 7QK0 (X-ray 1.96A ) 7RV3 (X-ray 1.35A ) 7RV4 (X-ray 1.25A ) 7RV5 (X-ray 2.21A ) 7RV6 (X-ray 1.68A ) 7RV7 (X-ray 1.63A ) 7RV8 (X-ray 1.25A ) 7RV9 (X-ray 1.50A ) |
| DBSNP | rs34463990 rs2229362 rs1056936 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356}. |
| Mouse PG classification | NA |
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