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Gene Information
Gene Name
BCL2L3
Organism
Homo sapiens (Human)
Gene Length
350
Protein Names
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
Q07820
Gene Card
MCL1
Uniprot ID
Q07820
Pfam
PF00452
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.042424(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2KBW
(NMR
-
)
2MHS
(NMR
-
)
2NL9
(X-ray
1.55A
)
2NLA
(X-ray
2.80A
)
2PQK
(X-ray
2.00A
)
3D7V
(X-ray
2.03A
)
3IO9
(X-ray
2.40A
)
3KJ0
(X-ray
1.70A
)
3KJ1
(X-ray
1.94A
)
3KJ2
(X-ray
2.35A
)
3KZ0
(X-ray
2.35A
)
3MK8
(X-ray
2.32A
)
3PK1
(X-ray
2.49A
)
3TWU
(X-ray
1.80A
)
3WIX
(X-ray
1.90A
)
3WIY
(X-ray
2.15A
)
4BPI
(X-ray
1.98A
)
4BPJ
(X-ray
1.60A
)
4HW2
(X-ray
2.80A
)
4HW3
(X-ray
2.40A
)
4HW4
(X-ray
1.53A
)
4OQ5
(X-ray
2.86A
)
4OQ6
(X-ray
1.81A
)
4WGI
(X-ray
1.85A
)
4WMR
(X-ray
1.70A
)
4WMS
(X-ray
1.90A
)
4WMT
(X-ray
2.35A
)
4WMU
(X-ray
1.55A
)
4WMV
(X-ray
2.40A
)
4WMW
(X-ray
1.90A
)
4WMX
(X-ray
2.00A
)
4ZBF
(X-ray
2.20A
)
4ZBI
(X-ray
2.50A
)
5C3F
(X-ray
1.43A
)
5C6H
(X-ray
2.05A
)
5FC4
(X-ray
1.50A
)
5FDO
(X-ray
2.80A
)
5FDR
(X-ray
2.60A
)
5IEZ
(X-ray
2.60A
)
5IF4
(X-ray
2.39A
)
5JSB
(X-ray
2.74A
)
5KU9
(X-ray
2.20A
)
5LOF
(X-ray
2.20A
)
5MES
(X-ray
2.24A
)
5MEV
(X-ray
2.94A
)
5UUM
(X-ray
2.35A
)
5VKC
(X-ray
2.31A
)
5VX2
(X-ray
1.85A
)
5W89
(X-ray
1.42A
)
5W8F
(X-ray
1.85A
)
6B4L
(X-ray
2.25A
)
6B4U
(X-ray
1.95A
)
6BW2
(X-ray
2.75A
)
6BW8
(X-ray
2.90A
)
6FS0
(X-ray
2.25A
)
6FS1
(X-ray
1.60A
)
6FS2
(X-ray
2.55A
)
6MBD
(X-ray
1.95A
)
6MBE
(X-ray
2.25A
)
6NE5
(X-ray
1.85A
)
6O4U
(X-ray
1.70A
)
6O6F
(X-ray
1.60A
)
6O6G
(X-ray
2.40A
)
6OQB
(X-ray
1.60A
)
6OQC
(X-ray
1.80A
)
6OQD
(X-ray
1.48A
)
6OQN
(X-ray
1.70A
)
6OVC
(NMR
-
)
6P3P
(X-ray
1.61A
)
6QB3
(X-ray
1.90A
)
6QB4
(X-ray
2.38A
)
6QB6
(X-ray
2.24A
)
6QFC
(X-ray
1.96A
)
6QFI
(X-ray
2.40A
)
6QFM
(X-ray
2.00A
)
6QFQ
(X-ray
1.60A
)
6QGD
(X-ray
1.80A
)
6QXJ
(X-ray
1.70A
)
6QYK
(X-ray
2.30A
)
6QYL
(X-ray
2.20A
)
6QYN
(X-ray
2.50A
)
6QYO
(X-ray
2.10A
)
6QYP
(X-ray
2.20A
)
6QZ5
(X-ray
2.00A
)
6QZ6
(X-ray
1.90A
)
6QZ7
(X-ray
2.20A
)
6QZ8
(X-ray
2.15A
)
6QZB
(X-ray
2.00A
)
6STJ
(X-ray
2.20A
)
6U63
(X-ray
2.75A
)
6U64
(X-ray
2.55A
)
6U65
(X-ray
2.09A
)
6U67
(X-ray
1.84A
)
6U6F
(X-ray
2.90A
)
6UA3
(X-ray
1.55A
)
6UAB
(X-ray
2.10A
)
6UD2
(X-ray
1.70A
)
6UDI
(X-ray
1.94A
)
6UDT
(X-ray
1.50A
)
6UDU
(X-ray
1.75A
)
6UDV
(X-ray
1.35A
)
6UDX
(X-ray
1.70A
)
6UDY
(X-ray
1.70A
)
6VBX
(X-ray
1.95A
)
6YBG
(X-ray
2.10A
)
6YBJ
(X-ray
2.50A
)
6YBK
(X-ray
2.00A
)
6YBL
(X-ray
2.10A
)
6ZIE
(X-ray
2.30A
)
7NB4
(X-ray
1.90A
)
7NB7
(X-ray
2.82A
)
7XGE
(X-ray
2.38A
)
DBSNP
rs2737820
rs11580946
rs140449444
Subcellular location [CC]
Membrane {ECO:0000305};
Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Mouse PG classification
NA
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