| Gene Information | |
|---|---|
| Gene Name | GZMA |
| Organism | Homo sapiens (Human) |
| Gene Length | 262 |
| Protein Names | Granzyme A (EC 3.4.21.78) (CTL tryptase) (Cytotoxic T-lymphocyte proteinase 1) (Fragmentin-1) (Granzyme-1) (Hanukkah factor) (H factor) (HF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000145649 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P12544 |
| Gene Card | GZMA |
| Uniprot ID | P12544 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.255583143) |
| Ortholog in Animals | Alpaca_ GZMA ( ortholog_one2one ) Dog_ GZMA ( ortholog_one2one ) GuineaPig_ GZMA ( ortholog_one2one ) Macaque_ GZMA ( ortholog_one2one ) Mouse_ Gzma ( ortholog_one2one ) Pig_ GZMA ( ortholog_one2one ) Rat_ Gzma ( ortholog_one2one ) |
| Ohnologs | CTSG, GZMB |
| Paralogs | MST1, PIK3IP1, HABP2, GZMK, HGF |
| Tissue | spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1OP8 (X-ray 2.50A ) 1ORF (X-ray 2.40A ) |
| DBSNP | rs3104233 |
| Subcellular location [CC] | [Isoform alpha]: Secreted {ECO:0000269|PubMed:3257574}. Cytoplasmic granule {ECO:0000269|PubMed:3257574}. Note=Delivered into the target cell by perforin. {ECO:0000269|PubMed:20038786, ECO:0000269|PubMed:32299851}. |
| Mouse PG classification | NA |
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