| Gene Information | |
|---|---|
| Gene Name | BCL2L11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000153094 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O43521 |
| Gene Card | BCL2L11 |
| Uniprot ID | O43521 |
| Pfam | PF08945; PF06773 |
| In ASD | no |
| Allosteric Prediction | yes (0.318731015) |
| Ortholog in Animals | Alpaca_ BCL2L11 ( ortholog_one2one ) Dog_ BCL2L11 ( ortholog_one2one ) GuineaPig_ BCL2L11 ( ortholog_one2one ) Macaque_ BCL2L11 ( ortholog_one2one ) Mouse_ Bcl2l11 ( ortholog_one2one ) Pig_ BCL2L11 ( ortholog_one2one ) Rat_ Bcl2l11 ( ortholog_one2one ) Rabbit_ BCL2L11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MEI1, SCIMP |
| Tissue | NA |
| Tissue Specificity | Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. {ECO:0000269|PubMed:12019181}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003599(Rat);0.151744(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1F95 (NMR - ) 2K7W (NMR - ) 2NL9 (X-ray 1.55A ) 2V6Q (X-ray 2.70A ) 2VM6 (X-ray 2.20A ) 2WH6 (X-ray 1.50A ) 2YQ6 (X-ray 1.80A ) 2YQ7 (X-ray 1.90A ) 3D7V (X-ray 2.03A ) 3FDL (X-ray 1.78A ) 3IO8 (X-ray 2.30A ) 3IO9 (X-ray 2.40A ) 3KJ0 (X-ray 1.70A ) 3KJ1 (X-ray 1.94A ) 3KJ2 (X-ray 2.35A ) 4A1U (X-ray 1.54A ) 4A1W (X-ray 2.50A ) 4B4S (X-ray 1.90A ) 4D2M (X-ray 2.10A ) 4QVF (X-ray 1.53A ) 4UF3 (X-ray 2.70A ) 4YJ4 (X-ray 2.10A ) 4ZIE (X-ray 1.80A ) 4ZIF (X-ray 2.40A ) 4ZIH (X-ray 2.50A ) 5AGW (X-ray 2.69A ) 5AGX (X-ray 2.24A ) 5C3G (X-ray 2.45A ) 5VWV (X-ray 1.90A ) 5VWW (X-ray 2.80A ) 5VWX (X-ray 2.49A ) 5VWY (X-ray 1.55A ) 5VWZ (X-ray 1.62A ) 5VX0 (X-ray 1.60A ) 5VX2 (X-ray 1.85A ) 5VX3 (X-ray 1.95A ) 5WOS (X-ray 2.45A ) 6QFI (X-ray 2.40A ) 6RJP (X-ray 2.57A ) 6TQQ (X-ray 3.00A ) 6UA3 (X-ray 1.55A ) 6UAB (X-ray 2.10A ) 6VBX (X-ray 1.95A ) 6X8O (X-ray 1.31A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.; [Isoform BimEL]: Mitochondrion. Note=Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion. |
| Mouse PG classification | NA |
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