| Gene Information | |
|---|---|
| Gene Name | BCL2L |
| Organism | Homo sapiens (Human) |
| Gene Length | 233 |
| Protein Names | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q07817 |
| Gene Card | BCL2L1 |
| Uniprot ID | Q07817 |
| Pfam | PF00452; PF02180 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| Pharmacological Animal Models | 0.025380(Chimpanzee);0.019071(Mouse);0.001416(Rat);0.128193(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BXL (NMR - ) 1G5J (NMR - ) 1LXL (NMR - ) 1MAZ (X-ray 2.20A ) 1R2D (X-ray 1.95A ) 1R2E (X-ray 2.10A ) 1R2G (X-ray 2.70A ) 1R2H (X-ray 2.20A ) 1R2I (X-ray 2.00A ) 1YSG (NMR - ) 1YSI (NMR - ) 1YSN (NMR - ) 2B48 (X-ray 3.45A ) 2LP8 (NMR - ) 2LPC (NMR - ) 2M03 (NMR - ) 2M04 (NMR - ) 2ME8 (NMR - ) 2ME9 (NMR - ) 2MEJ (NMR - ) 2O1Y (NMR - ) 2O2M (NMR - ) 2O2N (NMR - ) 2P1L (X-ray 2.50A ) 2PON (NMR - ) 2YJ1 (X-ray 2.24A ) 2YQ6 (X-ray 1.80A ) 2YQ7 (X-ray 1.90A ) 2YXJ (X-ray 2.20A ) 3CVA (X-ray 2.70A ) 3FDL (X-ray 1.78A ) 3FDM (X-ray 2.26A ) 3INQ (X-ray 2.00A ) 3IO8 (X-ray 2.30A ) 3PL7 (X-ray 2.61A ) 3QKD (X-ray 2.02A ) 3R85 (X-ray 1.95A ) 3SP7 (X-ray 1.40A ) 3SPF (X-ray 1.70A ) 3WIZ (X-ray 2.45A ) 3ZK6 (X-ray 2.48A ) 3ZLN (X-ray 2.29A ) 3ZLO (X-ray 2.60A ) 3ZLR (X-ray 2.03A ) 4A1U (X-ray 1.54A ) 4A1W (X-ray 2.50A ) 4AQ3 (X-ray 2.40A ) 4BPK (X-ray 1.76A ) 4C52 (X-ray 2.05A ) 4C5D (X-ray 2.30A ) 4CIN (X-ray 2.69A ) 4EHR (X-ray 2.09A ) 4HNJ (X-ray 2.90A ) 4IEH (X-ray 2.10A ) 4PPI (X-ray 2.85A ) 4QVE (X-ray 2.05A ) 4QVF (X-ray 1.53A ) 4QVX (X-ray 2.10A ) 4TUH (X-ray 1.80A ) 4Z9V (X-ray 2.10A ) 5AGW (X-ray 2.69A ) 5AGX (X-ray 2.24A ) 5B1Z (X-ray 2.15A ) 5C3G (X-ray 2.45A ) 5FMJ (X-ray 2.43A ) 5FMK (X-ray 1.73A ) 5VAY (X-ray 1.80A ) 5VX3 (X-ray 1.95A ) 6BF2 (NMR - ) 6DCN (X-ray 2.44A ) 6DCO (X-ray 2.20A ) 6F46 (NMR - ) 6HJL (X-ray 2.20A ) 6IJQ (NMR - ) 6LHD (X-ray 2.50A ) 6O0K (X-ray 1.62A ) 6O0L (X-ray 2.20A ) 6O0M (X-ray 1.75A ) 6O0O (X-ray 2.00A ) 6O0P (X-ray 1.80A ) 6RNU (X-ray 2.40A ) 6ST2 (X-ray 1.79A ) 6UVC (X-ray 1.90A ) 6UVD (X-ray 2.15A ) 6UVE (X-ray 2.87A ) 6UVF (X-ray 2.24A ) 6UVG (X-ray 2.10A ) 6UVH (X-ray 2.19A ) 6VWC (X-ray 1.60A ) 6X7I (Other - ) 6YLI (X-ray 1.90A ) 6ZHC (X-ray 1.92A ) 7CA4 (X-ray 2.70A ) 7JGV (X-ray 2.05A ) 7JGW (X-ray 1.30A ) 7LH7 (X-ray 1.41A ) 7XGG (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform Bcl-X(L)]: Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}. |
| Mouse PG classification | NA |
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