| Gene Information | |
|---|---|
| Gene Name | BCL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 239 |
| Protein Names | Apoptosis regulator Bcl-2 |
| Target Name | bcl-2 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000171791 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P10415 |
| Gene Card | BCL2 |
| Uniprot ID | P10415 |
| Pfam | PF00452; PF02180 |
| In ASD | yes |
| Allosteric Prediction | yes (1.415649245) |
| Ortholog in Animals | Alpaca_ BCL2 ( ortholog_one2one ) Dog_ BCL2 ( ortholog_one2one ) GuineaPig_ BCL2 ( ortholog_one2one ) Macaque_ BCL2 ( ortholog_one2one ) Mouse_ Bcl2 ( ortholog_one2one ) Pig_ BCL2 ( ortholog_one2one ) Rat_ Bcl2 ( ortholog_one2one ) |
| Ohnologs | BCL2L1, BCL2L2 |
| Paralogs | BAX, BCL2L10, BOK, MCL1, BCL2A1, BAK1, BCL2L1, BCL2L2 |
| Tissue | NA |
| Tissue Specificity | Expressed in a variety of tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.174574(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1G5M (NMR - ) 1GJH (NMR - ) 1YSW (NMR - ) 2O21 (NMR - ) 2O22 (NMR - ) 2O2F (NMR - ) 2W3L (X-ray 2.10A ) 2XA0 (X-ray 2.70A ) 4AQ3 (X-ray 2.40A ) 4IEH (X-ray 2.10A ) 4LVT (X-ray 2.05A ) 4LXD (X-ray 1.90A ) 4MAN (X-ray 2.07A ) 5AGW (X-ray 2.69A ) 5AGX (X-ray 2.24A ) 5FCG (X-ray 2.10A ) 5JSN (X-ray 2.10A ) 5VAU (X-ray 1.75A ) 5VAX (X-ray 2.00A ) 5VAY (X-ray 1.80A ) 6GL8 (X-ray 1.40A ) 6IWB (X-ray 2.50A ) 6O0K (X-ray 1.62A ) 6O0L (X-ray 2.20A ) 6O0M (X-ray 1.75A ) 6O0O (X-ray 2.00A ) 6O0P (X-ray 1.80A ) 7LHB (X-ray 2.07A ) |
| DBSNP | rs1800477 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21358617, ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}. |
| Mouse PG classification | NA |
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