| Gene Information | |
|---|---|
| Gene Name | CBY1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 126 |
| Protein Names | Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000100211 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y3M2 |
| Gene Card | CBY1 |
| Uniprot ID | Q9Y3M2 |
| Pfam | PF14645 |
| In ASD | no |
| Allosteric Prediction | no (-0.829069469) |
| Ortholog in Animals | Alpaca_ CBY1 ( ortholog_one2one ) Dog_ CBY1 ( ortholog_one2many ) GuineaPig_ CBY1 ( ortholog_one2one ) Macaque_ CBY1 ( ortholog_one2one ) Mouse_ Cby1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CBY2, CBY3, CCDC70 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. {ECO:0000269|PubMed:12712206}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4WRQ (X-ray 2.41A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus speckle {ECO:0000269|PubMed:16424001}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Golgi apparatus. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16424001}. |
| Mouse PG classification | NA |
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