| Gene Information | |
|---|---|
| Gene Name | BCKDHA |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000248098 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P12694 |
| Gene Card | BCKDHA |
| Uniprot ID | P12694 |
| Pfam | PF00676 |
| In ASD | no |
| Allosteric Prediction | no (-0.103155655) |
| Ortholog in Animals | Alpaca_ BCKDHA ( ortholog_one2one ) Dog_ TMEM91 ( ortholog_one2one ) GuineaPig_ BCKDHA ( ortholog_one2one ) Macaque_ BCKDHA ( ortholog_one2one ) Mouse_ Bckdha ( ortholog_one2one ) Pig_ BCKDHA ( ortholog_one2one ) Rat_ Bckdha ( ortholog_one2one ) Rabbit_ BCKDHA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDHA1, PDHA2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DTW (X-ray 2.70A ) 1OLS (X-ray 1.85A ) 1OLU (X-ray 1.90A ) 1OLX (X-ray 2.25A ) 1U5B (X-ray 1.83A ) 1V11 (X-ray 1.95A ) 1V16 (X-ray 1.90A ) 1V1M (X-ray 2.00A ) 1V1R (X-ray 1.80A ) 1WCI (X-ray 1.84A ) 1X7W (X-ray 1.73A ) 1X7X (X-ray 2.10A ) 1X7Y (X-ray 1.57A ) 1X7Z (X-ray 1.72A ) 1X80 (X-ray 2.00A ) 2BEU (X-ray 1.89A ) 2BEV (X-ray 1.80A ) 2BEW (X-ray 1.79A ) 2BFB (X-ray 1.77A ) 2BFC (X-ray 1.64A ) 2BFD (X-ray 1.39A ) 2BFE (X-ray 1.69A ) 2BFF (X-ray 1.46A ) 2J9F (X-ray 1.88A ) |
| DBSNP | rs11549936 rs34442879 rs769688327 rs398123503 rs375785084 rs199599175 rs137852871 rs182923857 rs137852872 rs137852870 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | NA |
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