| Gene Information | |
|---|---|
| Gene Name | BCAS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 928 |
| Protein Names | BCAS3 microtubule associated cell migration factor (Breast carcinoma-amplified sequence 3) (GAOB1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000141376 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H6U6 |
| Gene Card | BCAS3 |
| Uniprot ID | Q9H6U6 |
| Pfam | PF12490 |
| In ASD | no |
| Allosteric Prediction | no (-0.526167013) |
| Ortholog in Animals | Alpaca_ BCAS3 ( ortholog_one2one ) Dog_ BCAS3 ( ortholog_one2one ) GuineaPig_ BCAS3 ( ortholog_one2one ) Macaque_ BCAS3 ( ortholog_one2one ) Mouse_ Bcas3 ( ortholog_one2one ) Pig_ BCAS3 ( ortholog_one2one ) Rat_ Bcas3 ( ortholog_one2one ) Rabbit_ BCAS3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines. {ECO:0000269|PubMed:12378525, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:18030336}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2643103 rs34712615 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17505058}. Cytoplasm {ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:18030336, ECO:0000269|PubMed:33499712}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CCN5}. Preautophagosomal structure {ECO:0000269|PubMed:33499712}. Note=Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712). {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}. |
| Mouse PG classification | NA |
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