| Gene Information | |
|---|---|
| Gene Name | BCAR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 870 |
| Protein Names | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000050820 ) 3 ( ENSG00000285460 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P56945 |
| Gene Card | BCAR1 |
| Uniprot ID | P56945 |
| Pfam | PF12026; PF08824; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.797569048) |
| Ortholog in Animals | Alpaca_ BCAR1 ( ortholog_one2one ) Dog_ BCAR1 ( ortholog_one2one ) GuineaPig_ BCAR1 ( ortholog_one2one ) Macaque_ BCAR1 ( ortholog_one2one ) Mouse_ Bcar1 ( ortholog_one2one ) Pig_ BCAR1 ( ortholog_one2one ) Rat_ Bcar1 ( ortholog_one2one ) Rabbit_ BCAR1 ( ortholog_one2one ) |
| Ohnologs | CASS4, NEDD9 |
| Paralogs | CASS4, EFS, NEDD9 |
| Tissue | NA |
| Tissue Specificity | Expressed in B-cells (at protein level) (PubMed:9020138). Widely expressed with an abundant expression in the testis (PubMed:10639512). Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512). {ECO:0000269|PubMed:10639512, ECO:0000269|PubMed:9020138}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.057102(Mouse);0.003404(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WYX (X-ray 1.14A ) 3T6G (X-ray 2.50A ) 5O2M (NMR - ) 5O2P (NMR - ) 5O2Q (NMR - ) |
| DBSNP | rs1035539 rs144989936 rs16957558 rs16957552 |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:12832404}. Cytoplasm {ECO:0000269|PubMed:12832404}. Cell projection, axon {ECO:0000250|UniProtKB:Q61140}. Note=Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140}. |
| Mouse PG classification | NA |
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