| Gene Information | |
|---|---|
| Gene Name | BBOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) |
| Target Name | gamma-butyrobetaine dioxygenase |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000129151 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O75936 |
| Gene Card | BBOX1 |
| Uniprot ID | O75936 |
| Pfam | PF06155; PF02668 |
| In ASD | no |
| Allosteric Prediction | no (-0.381086095) |
| Ortholog in Animals | Alpaca_ BBOX1 ( ortholog_one2one ) GuineaPig_ BBOX1 ( ortholog_one2one ) Macaque_ BBOX1 ( ortholog_one2one ) Mouse_ Bbox1 ( ortholog_one2one ) Pig_ BBOX1 ( ortholog_one2one ) Rat_ Bbox1 ( ortholog_one2one ) Rabbit_ BBOX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TMLHE |
| Tissue | kidney |
| Tissue Specificity | Highly expressed in kidney; moderately expressed in liver; very low expression in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3MS5 (X-ray 1.82A ) 3N6W (X-ray 2.00A ) 3O2G (X-ray 1.78A ) 4BG1 (X-ray 1.89A ) 4BGK (X-ray 2.18A ) 4BGM (X-ray 2.40A ) 4BHF (X-ray 2.05A ) 4BHG (X-ray 1.85A ) 4BHI (X-ray 2.15A ) 4C5W (X-ray 1.70A ) 4C8R (X-ray 2.82A ) 4CWD (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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