| Gene Information | |
|---|---|
| Gene Name | CHMP4C |
| Organism | Homo sapiens (Human) |
| Gene Length | 233 |
| Protein Names | Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000164695 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96CF2 |
| Gene Card | CHMP4C |
| Uniprot ID | Q96CF2 |
| Pfam | PF03357 |
| In ASD | no |
| Allosteric Prediction | no (-0.855473842) |
| Ortholog in Animals | Alpaca_ CHMP4C ( ortholog_one2one ) Dog_ CHMP4C ( ortholog_one2one ) GuineaPig_ CHMP4C ( ortholog_one2one ) Macaque_ CHMP4C ( ortholog_one2one ) Mouse_ Chmp4c ( ortholog_one2one ) Pig_ CHMP4C ( ortholog_one2one ) Rat_ Chmp4c ( ortholog_one2one ) Rabbit_ CHMP4C ( ortholog_one2one ) |
| Ohnologs | CHMP4B |
| Paralogs | CHMP5, CHMP4A, CHMP4B, CHMP7 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, spleen and kidney. {ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:14678797}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.540399(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3C3R (X-ray 2.02A ) 5MK3 (X-ray 2.00A ) 5V3R (X-ray 1.91A ) 5WA1 (X-ray 1.87A ) |
| DBSNP | rs35094336 |
| Subcellular location [CC] | Cytoplasm, cytosol. Late endosome membrane {ECO:0000305|PubMed:14583093}; Peripheral membrane protein {ECO:0000305}. Midbody, Midbody ring {ECO:0000269|PubMed:22422861}. Note=Localizes to the midbody during late cytokinesis. During its recruitment, localizes initially to the midbody arms, before being directed to the central region, the midbody ring, also called Flemming body. Phosphorylation at Ser-210 by AURKB triggers localization to midbody ring. {ECO:0000269|PubMed:22422861}. |
| Mouse PG classification | NA |
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