| Gene Information | |
|---|---|
| Gene Name | BATF |
| Organism | Homo sapiens (Human) |
| Gene Length | 125 |
| Protein Names | Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) (SF-HT-activated gene 2 protein) (SFA-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000156127 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q16520 |
| Gene Card | BATF |
| Uniprot ID | Q16520 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | no (-0.980645231) |
| Ortholog in Animals | Alpaca_ BATF ( ortholog_one2one ) Dog_ BATF ( ortholog_one2one ) GuineaPig_ BATF ( ortholog_one2one ) Macaque_ BATF ( ortholog_one2one ) Mouse_ Batf ( ortholog_one2one ) Pig_ BATF ( ortholog_one2one ) Rat_ Batf ( ortholog_one2one ) Rabbit_ BATF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FOSL1, FOSL2, JDP2, ATF3, FOS, BATF3, BATF2, FOSB |
| Tissue | adipose.tissue, lung, spleen, whole.blood |
| Tissue Specificity | Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209). {ECO:0000269|PubMed:10777209, ECO:0000269|PubMed:8570175, ECO:0000269|PubMed:8630063}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}. |
| Mouse PG classification | NA |
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