| Gene Information | |
|---|---|
| Gene Name | DRC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 495 |
| Protein Names | Cornulin (53 kDa putative calcium-binding protein) (53 kDa squamous epithelial-induced stress protein) (58 kDa heat shock protein) (Squamous epithelial heat shock protein 53) (Tumor-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000157856 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBG3 |
| Gene Card | CRNN |
| Uniprot ID | Q9UBG3 |
| Pfam | PF01023 |
| In ASD | no |
| Allosteric Prediction | no (-1.762883135) |
| Ortholog in Animals | Alpaca_ DRC1 ( ortholog_one2one ) Dog_ SELENOI ( ortholog_one2one ) GuineaPig_ DRC1 ( ortholog_one2one ) Macaque_ SELENOI ( ortholog_one2one ) Mouse_ Drc1 ( ortholog_one2one ) Pig_ DRC1 ( ortholog_one2one ) Rat_ Drc1 ( ortholog_one2one ) Rabbit_ DRC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCDC65 |
| Tissue | testis, oviduct, caudate.nucleus, epididymis, medulla.oblongata |
| Tissue Specificity | Expressed in the basal skin layer (at protein level) (PubMed:30009832). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). {ECO:0000269|PubMed:11056050, ECO:0000269|PubMed:11606197, ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16466100, ECO:0000269|PubMed:16640557, ECO:0000269|PubMed:17289885, ECO:0000269|PubMed:30009832}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35639220 rs6695830 rs3829868 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1. |
| Mouse PG classification | NA |
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