| Gene Information | |
|---|---|
| Gene Name | FEM1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 627 |
| Protein Names | Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000169018 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UK73 |
| Gene Card | FEM1B |
| Uniprot ID | Q9UK73 |
| Pfam | PF00023; PF12796 |
| In ASD | no |
| Allosteric Prediction | no (-0.769763227) |
| Ortholog in Animals | Alpaca_ FEM1B ( ortholog_one2one ) Dog_ FEM1B ( ortholog_one2one ) GuineaPig_ FEM1B ( ortholog_one2one ) Macaque_ FEM1B ( ortholog_one2one ) Mouse_ Fem1b ( ortholog_one2one ) Pig_ FEM1B ( ortholog_one2one ) Rat_ Fem1b ( ortholog_one2one ) Rabbit_ FEM1B ( ortholog_one2one ) |
| Ohnologs | FEM1A, FEM1C |
| Paralogs | FEM1A, ANKRD33, ANKRD33B, FEM1C |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:10542291). Highly expressed in testis (PubMed:10542291). Weakly expressed in other tissues (PubMed:10542291). {ECO:0000269|PubMed:10542291}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6LBF (X-ray 3.25A ) 7CNG (X-ray 3.49A ) 7EL6 (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19330022, ECO:0000269|PubMed:24076122}. Nucleus {ECO:0000269|PubMed:19330022}. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment (PubMed:19330022). Associated with chromatin (PubMed:19330022). {ECO:0000269|PubMed:19330022}. |
| Mouse PG classification | NA |
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